USF vs. Memphis Football Prediction & Odds - Oct. 25

The No. 18 South Florida Bulls (6-1) square off against a fellow AAC foe when they visit the Memphis Tigers (6-1) on Saturday, October 25, 2025 at Simmons Bank Liberty Stadium.

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South Florida vs. Memphis Matchup Info

  • Game date: Saturday, October 25, 2025
  • Game time: 12 p.m. ET
  • Location: Memphis, Tennessee
  • Venue: Simmons Bank Liberty Stadium
  • TV channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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South Florida vs. Memphis Odds and Prediction

  • Spread favorite: Bulls (-6)
  • Moneyline: Bulls (-220), Tigers (+181)
  • Total: 58.5 points
  • Pick ATS: South Florida (-6)
  • Pick OU: Over (58.5)
  • Prediction: South Florida 34, Memphis 26

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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South Florida vs. Memphis Betting Records and Insights

  • South Florida has compiled a 5-1-1 ATS record so far this year.
  • Memphis has covered six times in seven games with a spread this year.
  • The Bulls have covered the spread twice this season (2-0-1 ATS) when playing as at least 6-point favorites.
  • The Tigers have covered the spread when playing as at least 6-point underdogs in their only opportunity this season.
  • South Florida and its opponent have combined to go over the point total four out of seven times this season.
  • This season, games featuring Memphis have hit the over twice.

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