Panthers vs. Senators Prediction & Picks - Oct. 21

The Florida Panthers (5-2-2) will try to extend a three-game win streak when they face the Ottawa Senators (6-3) on the road on Wednesday, Oct. 21 at 7:30 p.m. ET on ESPN+.

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Before this matchup, here is who we project to emerge victorious in Wednesday's hockey contest.

Panthers vs. Senators Predictions for Wednesday

Our computer model for this matchup calls for a final result of Senators 4, Panthers 3.

• Moneyline Pick: Senators (-111)
• Total Pick: Under 6 (computer predicts 5.7 goals on average)
• Spread Pick: Senators (+1.5)

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Senators Splits and Trends

• The Senators are 6-3 overall and 2-0-2 in overtime contests.
• Ottawa has won both of its games that were decided by one goal.
• In the two games this season the Senators registered only one goal, they've finished 1-1-0 (two points).
• Ottawa has finished 2-1-0 in the three games this season when it scored exactly two goals (registering four points).
• The Senators have scored three or more goals four times, and are 3-1-0 in those games (to register six points).
• In the five games when Ottawa has capitalized on a single power-play goal, it went 3-2-0 to record six points.
• In games when it has outshot its opponent, Ottawa is undefeated (2-0-0, four points).
• The Senators' opponents have had more shots in six games. The Senators went 3-3-0 in those matchups (six points).

Panthers Splits and Trends

• The Panthers have a 5-2-2 record this season and are 2-2-4 in contests that have needed overtime.
• Florida has earned eight points (3-0-2) in its five games decided by one goal.
• This season the Panthers registered only one goal in two games and they've earned two points (1-1-0) in those contests.
• Florida has three points (1-0-1) when scoring exactly two goals this season.
• The Panthers have scored more than two goals in five games, earning seven points from those contests.
• Florida has scored a single power-play goal in one game this season and lost in overtime.
• When it outshoots its opponent this season, Florida has posted a record of 5-1-1 (11 points).
• The Panthers have been outshot by opponents twice, and earned a single point in those games.

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Team Stats Comparison

Panthers vs. Senators Game Time and TV Channel

• When: Wednesday, October 21, 2026 at 7:30 p.m. ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+
• Where: Canadian Tire Centre in Ottawa, Ontario

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